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The History series contains one record book, created around 1905, in which Nu Sigma Nu Alpha Chapter members of early years would eventually write their autobiographies. Although it is only partially completed, the book contains pages of autobiographical information about Nu Sigma Nu men and their careers in medicine. A separate folder within that file contains non-dated historical information about the founding and development of the fraternity in general, presumably written for publication in annual bulletins or alumni newsletters. In addition to written documents, there exist two artifacts within the History series: the original charter from 1882 and the crest of Nu Sigma Nu.

The Housing series contains two subseries: 1906 House (1015 E. Huron) and 1969 House (1912 Geddes). There have been two permanent chapter houses of the Alpha Chapter of Nu Sigma Nu: the house built at 1015 East Huron Avenue in 1906 and the house built at 1912 Geddes Avenue in 1969. Within the subseries 1906 House (1015 E. Huron) there exist legal documents, insurance policies taken out for the house, and a record of house inspections done by the Housing Division of the University of Michigan. Information pertaining to the construction of the 1906 house can be found in the Correspondence series, in the subseries Building Correspondence. The subseries 1969 House (1912 Geddes) contains similar records, as well as information on the campaign to build the second chapter house, how the house was furnished, and individual incidents that occurred while the house was in use. Financial documents relating to the houses can be found in the series Financial Records.