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The Research series is composed of two subseries: Industrial Research and Government Research. The extent of documentation varies considerably among individual projects, but may include correspondence, reports, notes, photographs and experimental data, and budget information. Each subseries consists of separate files for the various sponsored projects involving Dow as a director or participant. The Industrial Research subseries begins with a general correspondence file; the remainder of the materials are arranged alphabetically by the name of the sponsoring company. Where a project number has been identified, it is included in the folder title. Among the more significant of these projects is Dow's work for the Fisher Body Division of General Motors on the use of high-frequency power for welding sheet metal (which resulted in several patents).

The Government Research subseries begins with projects which could not be identified by a project number, listed alphabetically. The remainder of the folders in the subseries are organized by project number. The following materials are particularly significant: Project 669 which employed U-2 rockets in investigations of the ionosphere; Project 679, (or "Wizard") which involved development of guidance systems for an anti-ballistic missile, and Project M2144, (known as "Wolverine," and later "Project Michigan") which encompassed a wide range of military sponsored research.