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A unit of the University of Michigan's Institute of Science and Technology which conducts and sponsors interdisciplinary studies of fresh water lake ecology. It is the successor to the Great Lakes Research Institute and the Great Lakes Research Division of the University of Michigan. Primarily research data, analysis, and reports on two major studies: the Coherent Area Study of Lake Michigan, 1963-1971, and the Donald C. Cook Nuclear Power Plant Studies, 1967-1983.

The records in this collection are largely research files from the period when John C. Ayers was director of research for the Great Lakes Research Division. The bulk of the records document two large research projects: the Coherent Area Study, 1963-1971, and Donald C. Cook Nuclear Power Plant Studies, 1967-1983. There is also documentation of several smaller research projects. The research files include reports, field and laboratory data, and a variety of logs documenting data collection. The collection has few if any administrative records of the GLRD or its successors.

The records are arranged in ten series: Historical Information, Coherent Area Study, Ship's Logs, Donald C. Cook Power Plant Studies, Lake Michigan Ice Studies, John C. Ayers Research Files, Administration, Grants, Topical files, and Visual materials. Because the records contain a variety of formats, including slides, fan-fold computer printouts, and outsize volumes, some subgroups and series are split between ranges of box numbers. The summary contents list provides an overview of the physical arrangement of the records.