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Registered nurse and artist from Grand Rapids, Michigan and Tucson, Arizona. Letters exchanged with William Butler during their courtship and the first months of their marriage, 1923-1925; diaries, 1915-1979, detailing daily life and observations; subject files relating in part to her interest in nursing and sculpture.

The Irene Butler collection consists of four series of papers: Personal/Biographical, Correspondence, Diaries, and Artistic Endeavors. Together these series reflect Butler's lively mind and her awareness of the world about her.