Resident of Wooster, Ohio (later of Bedford, Iowa); 1862 graduate of the University of Michigan Department of Medicine and Surgery; surgeon in the 20th Ohio Volunteer Infantry during the Civil War. Civil War letters, diaries, newspapers, miscellanea and photographs; Civil War letters of his brother John Guthrie, also with the 20th Ohio Volunteer Infantry; and manuscript biography written by Helen Stephenson Guthrie.
The collection consists of school records, and correspondence and other documents relating to his Civil War service and activities.