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Unit of the University of Michigan Medical School. Records include minutes of meetings of senior staff members; also other materials concerning intern and residency training, and scattered correspondence and lecture notes; includes chairperson's files of John M. Carethers, John Del Valle, H. David Humes, William N. Kelley, Marc Lippman, Lawrence McMahon, and Tadataka Yamada. Also included are divisional files, administrative records, and photographs (including negatives and proofs) of faculty and staff.

The records of the department have arrived in five separate accessions in 1986, 1992, 1998, 2014, and 2018.

The 1992 accession of the records of the Department of Internal Medicine are primarily from the years when William Kelley served as chair (1975-1989). The accession is divided into five series: Division Files, Topical Files, Meeting Minutes, Chairperson's Files, and Pollard Medical Research Institute.

The 1998 accession contains the files of Chris Durovich, the Chief Administrator of the Department of Internal Medicine and covers the period from 1990 to 1996. As one would expect given this origin, these materials are focused more on the administration of the department than on its medical mission. The many topical files relating to managed care and organizational restructuring (such as the Cost Effectiveness Program (CEP), Redesign Coordinating Group, and Structure Work Group) reveal the many pressures on the department during this period. Durovich was also active in many inter and intradepartmental committees and workgroups, including the Clinical Departmental Administrators and meetings. This accession is divided into two series: Topical Files and Financial Files.

The 2014 accession is divided into five series: Division Files, Chairperson's Files, Financial Files, Topical Files, and Photographs. Material includes correspondence of former key figures, including department chairs Drs. William N. Kelley (1975-1989), Tadataka Yamada (1990-1996), H. David Humes (1996-2000), and John M. Carethers (2009-present), Medical School Dean Giles G. Bole Jr. (1990-1996), and George D. Zuidema (professor of surgery and Vice Provost Emeritus for Medical Affairs/1984-1994). Other materials highlight the department's efforts to attract and honor outstanding faculty and staff, monitor on-going operations, identify issues, gather and evaluate information, and recommend courses of action. These materials also shed light on the department's need to allocate additional work spaces, develop specific programs for education, training, research, and practice, and manage finances. These facets are all evident as researchers will discover files pertaining to faculty awards, committees, space planning proposals, events, program descriptions, financial data, and images of faculty and staff. The 2018 accession contains materials related to the department's Medical Ethics Committee dated in the 1990s. Included are questionnaires completed by staff physicians with narratives about situations relevant to professional ethics in their daily work.

Molecular Medicine and Genetics Division established within the Department of Internal Medicine in 1991 to coordinate aspects of University of Michigan research as part of the Human Genome Project, an international effort to identify and map the genetic structure of the human chromosomes. Planning records from the University of Michigan Internal Medicine Molecular Medicine and Genetics Division relating to the unit's participation in human gene therapy; include minutes, development and feasibility studies, and a copy of the program proposal, "Experimental Models of Gene Therapy."

The records of the University of Michigan Department of Internal Medicine Molecular Medicine and Genetics Division, dating from 1988 to 1992, document some of the earliest gene therapy endeavors, centering on successful efforts to establish a Human Genome Center at the university. The bulk of the records focus on the development of the program project grant, "Experimental Models of Gene Therapy." The collection, organized in four series, includes Human Gene Therapy Initiative (an early effort to establish a Human Genome Center at the University of Michigan), Scientific Basis for Gene Therapy, Experimental Models of Gene Therapy, and Center for Excellence in Gene Therapy files. The organization of the series reflects the general chronology of the development of gene therapy research at the University of Michigan