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The collection is comprised of annual reports, brochures and pamphlets, programs, proposals, and reports from the Department of Internal Medicine. This includes publications from subunits and related clinics such as the Frankel Cardiovascular Center, the Committee on Medical Ethics, the Division of Molecular and Human Genetics, the Division of General Medicine, and the Medical Center.

The Department of Internal Medicine Publications contains two series, Unit Publications and Sub-Unit Publications. The Unit Publications series contains printed material published specifically by the Department of Internal Medicine. These publications are defined as being widely distributed and may be published at regular intervals. They are arranged by genre of the publication. The Sub-Unit Publications series contains publications from subordinate offices, departments, programs and organizations within the Department of Internal Medicine. These publications are arranged alphabetically by the creating sub-unit.

Unit of the University of Michigan Medical School. Records include minutes of meetings of senior staff members; also other materials concerning intern and residency training, and scattered correspondence and lecture notes; includes chairperson's files of John M. Carethers, John Del Valle, H. David Humes, William N. Kelley, Marc Lippman, Lawrence McMahon, and Tadataka Yamada. Also included are divisional files, administrative records, and photographs (including negatives and proofs) of faculty and staff.

The records of the department have arrived in five separate accessions in 1986, 1992, 1998, 2014, and 2018.

The 1992 accession of the records of the Department of Internal Medicine are primarily from the years when William Kelley served as chair (1975-1989). The accession is divided into five series: Division Files, Topical Files, Meeting Minutes, Chairperson's Files, and Pollard Medical Research Institute.

The 1998 accession contains the files of Chris Durovich, the Chief Administrator of the Department of Internal Medicine and covers the period from 1990 to 1996. As one would expect given this origin, these materials are focused more on the administration of the department than on its medical mission. The many topical files relating to managed care and organizational restructuring (such as the Cost Effectiveness Program (CEP), Redesign Coordinating Group, and Structure Work Group) reveal the many pressures on the department during this period. Durovich was also active in many inter and intradepartmental committees and workgroups, including the Clinical Departmental Administrators and meetings. This accession is divided into two series: Topical Files and Financial Files.

The 2014 accession is divided into five series: Division Files, Chairperson's Files, Financial Files, Topical Files, and Photographs. Material includes correspondence of former key figures, including department chairs Drs. William N. Kelley (1975-1989), Tadataka Yamada (1990-1996), H. David Humes (1996-2000), and John M. Carethers (2009-present), Medical School Dean Giles G. Bole Jr. (1990-1996), and George D. Zuidema (professor of surgery and Vice Provost Emeritus for Medical Affairs/1984-1994). Other materials highlight the department's efforts to attract and honor outstanding faculty and staff, monitor on-going operations, identify issues, gather and evaluate information, and recommend courses of action. These materials also shed light on the department's need to allocate additional work spaces, develop specific programs for education, training, research, and practice, and manage finances. These facets are all evident as researchers will discover files pertaining to faculty awards, committees, space planning proposals, events, program descriptions, financial data, and images of faculty and staff. The 2018 accession contains materials related to the department's Medical Ethics Committee dated in the 1990s. Included are questionnaires completed by staff physicians with narratives about situations relevant to professional ethics in their daily work.

Stefan S. Fajans was a Professor of Internal Medicine at the University of Michigan Medical School from 1949-1988 and active Professor Emeritus of Internal Medicine until 2014. The collection includes personal correspondence during his time in the U.S. Army Medical Corps in World War II, as well as materials related to his professional activities and interests, including patient records, correspondence, lectures, manuscripts and other topical files related to his research on diabetes, especially Maturity Onset Diabetes of the Young (MODY).

The Stefan S. Fajans papers are comprised of personal correspondence with his family while in the U.S. Army Medical Corps during World War II as well as a wide range of materials documenting his professional life. The latter are a rich source for his research on Maturity Onset Diabetes of the Young (MODY) and its associated genetic markers. The Stefan S. Fajans papers are divided into two series: Personal Correspondence and Professional Files.