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The Nu Sigma Nu Fraternity was founded at the University of Michigan in 1882 and is the oldest medical fraternity in the United States. It was created to promote cooperation and fellowship among medical men and to raise medical education and scholarship to a higher level. These records document the creation of the Nu Sigma Nu fraternity and the history of the Alpha Chapter from its inception in 1882 to its termination in 2008.

The Nu Sigma Nu, Alpha Chapter collection contains records that relate to both the local chapter of Nu Sigma Nu as well as the founding of the national organization. Information within these records reveals the history of the fraternity, the daily business of the Alpha Chapter throughout its existence, and the interaction between the Alpha Chapter and the University of Michigan. These records are divided into eight series: Administration, Correspondence, Financial Records, History, Housing, Nu Sigma Nu Medical Scholarship Fund, Photographs, and Publications.