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Collection of correspondence belonging to De Witt and Sarah Clarke, who were residents of Battle Creek, Michigan during the Civil War. Bulk of collection consists of letters Sarah sent De Witt from Michigan while he was serving in the 2nd Missouri Cavalry. Remainder of the collection includes personal correspondence with other family members and friends as well as De Witt's business correspondence. Bulk of business correspondence dates after De Witt relocated the family to the developing town of Le Mars, Iowa in 1871, where he was a prominent merchant and community leader.

The collection consists of Sarah and De Witt Clarke's personal correspondence and De Witt's business correspondence. The bulk of the collection consists of letters from Sarah to De Witt, written from Michigan while De Witt was away with Merrill's Horse in Arkansas and Tennessee from 1864 to 1865. In her letters, Sarah expresses anxiety for her husband, reports on home and family life, and describes caring for their child in his absence. The collection includes De Witt Clarke's letters to his wife and personal correspondence with other family members and friends during and after the war. De Witt Clarke's business correspondence dates from after the Civil War and includes receipts, ledgers, price lists, notices, and advertisements, as well as correspondence with typewriter manufacturers in New York and Ohio.

Also included in the collection are typewritten transcriptions and lists of letters compiled by Anne Meis Knupfer.

Quaker abolitionist and physician in Mt. Pleasant, Ohio, and Schoolcraft, Michigan. Correspondence of Thomas, his wife Pamela S. Brown Thomas, and their children; addresses, autobiography, financial ledgers, and files relating to business activities, medical practice, and anti-slavery activities.

The collection is divided into two series: Correspondence and Other papers: anti-slavery, medical practice, and family.

The correspondence is of Thomas, his wife Pamela S. Brown Thomas, their children Ella, Malcolm, and Stanton, and relatives, friends, public leaders, abolitionists, and publishers. These letters deal largely with family affairs, land transactions, medical discoveries, woman suffrage, the Liberty Party, and Thomas's anti-slavery activities. There are also letters of Stanton B. Thomas while a student at the University of Michigan (1859-1864) and Civil War letters of S. B. Thayer, medical director of the Merrill Horse Regiment. Other Thomas papers include manuscript addresses, essays and other papers; a manuscript autobiography of Thomas; three account books, 1832-1879, pertaining mainly to his medical practice and other business affairs. Of interest is a prospectus for a newspaper, the American Freeman, which lists Schoolcraft area subscribers.